Ketamine Research — Overview
Since 2010, doctors have been prescribing ketamine in low doses to people with treatment resistant depression, but it may only be administered in the presence of a licensed physician.
The most recent research is showing that intravenous or intramuscular administration provides the best outcome, when using ketamine in psychedelic assisted therapy. The way ketamine works is similar to what we’ve learned about MDMA and psilocybin; Ketamine administration rapidly … increases the number, complexity, and strength of connections between neurons, and this effect appears to be directly correlated with its antidepressant benefit,” said Dr. Kelley O’Donnell, a psychiatrist who studies and provides psychedelic-assisted psychotherapy at New York University’s Langone Center for Psychedelic Medicine.
The belief is that ketamine, similar to studies on psilocybin, helps generate new connections between neurons that have been lost over time as a result of depression. We do know that ketamine causes a boost in the neurotransmitter, glutamate. Glutamate is known to stimulate new communication between brain cells that might have been damaged by stress and depression.
Research on Psychedelic Assisted Therapy
Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207256/
The New Yorker: Ketamine therapy is going mainstream. Are we ready? https://www.newyorker.com/culture/annals-of-inquiry/ketamine-therapy-is-going-mainstream-are-we-ready
The New York Times Podcast: “The Veterans Fighting to Legalize Psychedelics” https://www.nytimes.com/2023/02/22/podcasts/the-daily/veterans-psychedelics-legalization.html
The Harvard Gazette: “Ketamine found effective in treating severe depression” https://news.harvard.edu/gazette/story/2023/05/ketamine-found-effective-in-treatment-resistant-depression/
Johns Hopkins Psychedelic Research https://www.hopkinsmedicine.org/psychiatry/research/psychedelics-research
Michael Pollan “How to Change Your Mind” ( book and Netflix Series) https://michaelpollan.com/books/how-to-change-your-mind/
https://www.netflix.com/title/80229847
Gabor Mate “Psychedelics in the Treatment of Trauma” https://www.youtube.com/watch?v=SOGTqVt0dlQ
Bessel van der Kolk “Childhood Trauma, Psychedelics & EMDR” https://www.youtube.com/watch?v=XIH5taudtH0
Penn Medicine News “Penn Medicine Study Gives Peek of How Ketamine Acts as ‘Switch’ in the Brain” https://www.pennmedicine.org/news/news-releases/2022/december/a-peek-of-how-ketamine-acts-as-switch-in-the-brain
CNN “ How psilocybin, the psychedelic in mushrooms, may rewire the brain to ease depression, anxiety and more” https://www.cnn.com/2022/06/11/health/psilocybin-brain-changes-life-itself-wellness-scn/index.html
Stanford Medical School “Psychedelics” https://med.stanford.edu/spsg/about.html
Ketamine Research Institute “5 amazing things you need to know about ketamine infusion therapy” (anti-inflamatory, autoimmune treatment, reduce stress response and increase immune function, brain regeneration, Long haul COVID, addiction recovery) https://ketamineinstitute.com/ketamine-blog-news-and-recent-developments/5-amazing-things-you-need-to-know-about-ketamine-infusion-therapy/
Ketamine as a treatment for PTSD (Research article) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457782/
MDMA for Couples Therapy (research article) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631777/
Time Magazine “MDMA could Revolutionize Couples Therapy” https://time.com/6262291/psychedelics-mdma-couples-therapy/
Vice: “Couples Are Doing MDMA and Ketamine Therapy To Save Their Relationships”
https://www.vice.com/en/article/5d9yg5/ketamine-mdma-couples-therapy
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